منابع مشابه
Morphine and Clonidine Combination Therapy Improves Therapeutic Window in Mice: Synergy in Antinociceptive but Not in Sedative or Cardiovascular Effects
Opioids are used to manage all types of pain including acute, cancer, chronic neuropathic and inflammatory pain. Unfortunately, opioid-related adverse effects such as respiratory depression, tolerance, physical dependence and addiction have led to an underutilization of these compounds for adequate pain relief. One strategy to improve the therapeutic utility of opioids is to co-administer them ...
متن کاملElectroacupuncture, morphine and clonidine: a comparative study of analgesic effects.
This is a comparative study of the analgesic effects of the modified traditional method of analgesia, electroacupuncture (EA), a standard analgesic drug, morphine, a potential analgesic drug, clonidine and the combination of EA + morphine and EA + clonidine. In each case, the index of analgesia (IA) was determined by recording the tail flick latency (TFL) in 60 rats divided into 6 groups of 10 ...
متن کاملHyperpolarizing effects of morphine, clonidine and 2-chloroadenosine in myenteric neurons associated with tolerance to morphine.
Chronic treatment of guinea pigs with morphine produces non-specific subsensitivity (tolerance) of the longitudinal smooth muscle myenteric plexus (LM/MP) preparation of the guinea pig ileum to morphine, clonidine and 2-chloroadenosine correlated with a partial depolarization of myenteric S neurons. The purpose of our investigation was to gain further evidence regarding the cellular mechanism o...
متن کاملHypotensive and sedative effects of clonidine injected into the rostral ventrolateral medulla of conscious rats.
We examined the effects of clonidine injected unilaterally into the rostral ventrolateral medulla (RVLM) of conscious, unrestrained rats. We also examined whether the local alpha(2)-adrenoceptor mechanism contributed to the action of clonidine injected into the RVLM. Injection of clonidine but not vehicle solution significantly decreased the mean arterial pressure (MAP), heart rate (HR), and re...
متن کاملEffects of Sedative Medicines
تا سال ۱۹۵۰ داروی اختصاصی برای درمان نشانه های سایکوتیک در دسترس نبود. در سال ۱۹۵۲ برای اولین بار داروی کلرپرومازین در یک بیمارستان ارتش در حومه پاریس تجویز شد. دو سال بعد این دارو با نام «لارگاکتیل» در فرانسه مورد استفاده قرار گرفت. نام این دارو بازتابی از اثرات وسیع آن می باشد. کلرپرومازین با داروهای خواب آور ابتدایی مثل هیدرات کلرال و باربیتوراتهاه متفاوت بود، زیرا اثراتی بیش از خواب آوری دا...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2003
ISSN: 0007-0912
DOI: 10.1093/bja/aeg600